1cdm Summary

pdbe.org/1cdm
spacer

MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES

The structure was published by Meador, W.E., Means, A.R., and Quiocho, F.A., in 1993 in a paper entitled "Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PEPTIDE CALMODULIN-DEPENDENT PROTEIN KINASE II and CALMODULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEPTIDE CALMODULIN-DEPENDENT PROTEIN KINASE II P62157 (5-148) (CALM_BOVIN)search Bos taurussearch 95% 144 92%
B CALMODULIN P11275 (290-314) (KCC2A_RAT)search Rattus norvegicussearch < 90% 25 72%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62157 (5 - 148) PEPTIDE CALMODULIN-DEPENDENT PROTEIN KINASE II Bos taurus
P11275 (290 - 314) CALMODULIN

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62157) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
B

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62157) protein bindingsearch metal ion bindingsearch calcium ion bindingsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch cytoplasmsearch spindle polesearch cytoskeletonsearch cytosolsearch spindlesearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch