1cdl Summary

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TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX

The structure was published by Meador, W.E., Means, A.R., and Quiocho, F.A., in 1992 in a paper entitled "Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CALMODULIN and CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-148) (CALM_HUMAN)search Homo sapienssearch 97% 147 96%
B CALMODULIN P62158 (2-148) (CALM_HUMAN)search Homo sapienssearch 97% 147 96%
C CALMODULIN P62158 (2-148) (CALM_HUMAN)search Homo sapienssearch 97% 147 96%
D CALMODULIN P62158 (2-148) (CALM_HUMAN)search Homo sapienssearch 97% 147 96%
E CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11799 (1730-1749) (MYLK_CHICK)search Gallus gallussearch < 90% 20 100%
F CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11799 (1730-1749) (MYLK_CHICK)search Gallus gallussearch < 90% 20 100%
G CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11799 (1730-1749) (MYLK_CHICK)search Gallus gallussearch < 90% 20 100%
H CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN P11799 (1730-1749) (MYLK_CHICK)search Gallus gallussearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62158 (2 - 148) CALMODULIN Homo sapiens
P11799 (1730 - 1749) CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch
E, F, G, H

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P62158) calcium ion bindingsearch protein bindingsearch protein phosphatase activator activitysearch ion channel bindingsearch metal ion bindingsearch phospholipase bindingsearch thioesterase bindingsearch calcium-dependent protein bindingsearch titin bindingsearch phosphatidylinositol 3-kinase bindingsearch N-terminal myristoylation domain bindingsearch protein domain specific bindingsearch calcium channel complexsearch cytosolsearch spindle microtubulesearch plasma membranesearch nucleoplasmsearch spindle polesearch centrosomesearch extracellular regionsearch cytoplasmsearch spindlesearch cytoskeletonsearch sarcomeresearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch glucose metabolic processsearch synaptic transmissionsearch detection of calcium ionsearch blood coagulationsearch platelet degranulationsearch response to calcium ionsearch activation of phospholipase C activitysearch carbohydrate metabolic processsearch rhodopsin mediated signaling pathwaysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch inositol phosphate metabolic processsearch positive regulation of phosphoprotein phosphatase activitysearch positive regulation of cyclic nucleotide metabolic processsearch regulation of nitric-oxide synthase activitysearch fibroblast growth factor receptor signaling pathwaysearch regulation of heart ratesearch muscle contractionsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch innate immune responsesearch response to corticosterone stimulussearch small molecule metabolic processsearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch G-protein coupled receptor signaling pathwaysearch response to amphetaminesearch platelet activationsearch Fc-epsilon receptor signaling pathwaysearch regulation of cardiac muscle contractionsearch signal transductionsearch glycogen catabolic processsearch regulation of rhodopsin mediated signaling pathwaysearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch positive regulation of protein dephosphorylationsearch phototransduction, visible lightsearch nitric oxide metabolic processsearch regulation of cytokinesissearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch epidermal growth factor receptor signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Recoverin likesearch EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
E, F, G, H