1cdk Summary

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CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C

The structure was published by Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., and Huber, R., in 1993 in a paper entitled "Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CAMP-DEPENDENT PROTEIN KINASE and PROTEIN KINASE INHIBITOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CAMP-DEPENDENT PROTEIN KINASE P36887 (2-351) (KAPCA_PIG)search Sus scrofasearch 100% 350 98%
B CAMP-DEPENDENT PROTEIN KINASE P36887 (2-351) (KAPCA_PIG)search Sus scrofasearch 100% 350 98%
I PROTEIN KINASE INHIBITOR P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 100%
J PROTEIN KINASE INHIBITOR P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P36887 (2 - 351) CAMP-DEPENDENT PROTEIN KINASE Sus scrofa
P61926 (6 - 25) PROTEIN KINASE INHIBITOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P36887) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I, J cAMP-dependent protein kinase inhibitorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P36887) plasma membranesearch mitochondrionsearch nucleussearch cytoplasmsearch membranesearch ATP bindingsearch kinase activitysearch cAMP-dependent protein kinase activitysearch transferase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch phosphorylationsearch
I, J (P61926) cAMP-dependent protein kinase inhibitor activitysearch negative regulation of protein kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I, J cAMP-dependent protein kinase inhibitorsearch