› 1cdh

X-ray diffraction
2.3Å resolution

STRUCTURES OF AN HIV AND MHC BINDING FRAGMENT FROM HUMAN CD4 AS REFINED IN TWO CRYSTAL LATTICES

Released:
DOI: 10.2210/pdb1cdh/pdb
PDB entry 1cdh coloured by chain, front view.
PDB entry 1cdh coloured by chain, side view.
PDB entry 1cdh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices.
Ryu SE, Truneh A, Sweet RW, Hendrickson WA
Structure 2 59-74 (1994)
PMID: 8075984

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134559 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface glycoprotein CD4 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.73 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 83.71Å b: 30.01Å c: 87.54Å
α: 90° β: 117.28° γ: 90°
R-values:
R R work R free
0.193 0.193 not available
Expression system: Not provided

Quick links

Citations

8 review citations

Disulfide bonds as switches for protein function.
Hogg PJ. (2003)
7 more

7 mentions without citation

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.
Kwong et al. (1998)
6 more