1ccu Summary



The structure was published by Ippolito, J.A., Baird Jr., T.T., McGee, S.A., Christianson, D.W., and Fierke, C.A., in 1995 in a paper entitled "Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) response to pHsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch one-carbon metabolic processsearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch kidney developmentsearch response to estrogensearch regulation of intracellular pHsearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch response to steroid hormonesearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch cytosolsearch membranesearch plasma membranesearch microvillussearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch axonsearch basolateral plasma membranesearch apical part of cellsearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch