1ccs Summary

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STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY

The structure was published by Ippolito, J.A., Baird Jr., T.T., McGee, S.A., Christianson, D.W., and Fierke, C.A., in 1995 in a paper entitled "Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch response to pHsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch response to estrogensearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch kidney developmentsearch response to organic substancesearch response to zinc ionsearch secretionsearch small molecule metabolic processsearch regulation of chloride transportsearch membranesearch cytosolsearch myelin sheathsearch cytoplasmsearch plasma membranesearch extracellular vesicular exosomesearch apical part of cellsearch microvillussearch basolateral plasma membranesearch axonsearch extracellular spacesearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch