1cb8 Summary



The structure was published by Fethiere, J., Eggimann, B., and Cygler, M., in 1999 in a paper entitled "Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (CHONDROITINASE AC). This molecule has the UniProt identifier Q59288 (CSLA_PEDHD)search. The sample contained 678 residues which is 100% of the natural sequence. Out of 678 residues 668 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CHONDROITINASE AC) Q59288 (23-700) (CSLA_PEDHD)search Pedobacter heparinus DSM 2366search 100% 678 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q59288 (23 - 700) PROTEIN (CHONDROITINASE AC) Pedobacter heparinus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q59288) Hyaluronate lyase-like catalytic, N-terminal domainsearch, Hyaluronate lyase-like, C-terminal domainsearch, Hyaluronate lyase-like, central domainsearch Glycosyltransferasesearch, Beta-galactosidase; Chain A, domain 5search, Chondroitinase Ac; Chain A, domain 3search PF02278: Polysaccharide lyase family 8, super-sandwich domainsearch, PF02884: Polysaccharide lyase family 8, C-terminal beta-sandwich domainsearch, PF08124: Polysaccharide lyase family 8, N terminal alpha-helical domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q59288) carbohydrate metabolic processsearch lyase activitysearch carbohydrate bindingsearch catalytic activitysearch carbon-oxygen lyase activity, acting on polysaccharidessearch chondroitin AC lyase activitysearch metal ion bindingsearch extracellular regionsearch

Chain InterPro annotation
A Polysaccharide lyase family 8, central domainsearch Polysaccharide lyase family 8, C-terminalsearch Chondroitin AC/alginate lyasesearch Galactose mutarotase-like domainsearch Polysaccharide lyase family 8-like, C-terminalsearch Polysaccharide lyase family 8, N-terminalsearch Polysaccharide lyase 8, N-terminal alpha-helicalsearch Glycoside hydrolase-type carbohydrate-binding, subgroupsearch