1cb7 Summary

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GLUTAMATE MUTASE FROM CLOSTRIDIUM COCHLEARIUM RECONSTITUTED WITH METHYL-COBALAMIN

The structure was published by Reitzer, R., Gruber, K., Jogl, G., et al., Bothe, H., Buckel, W., and Kratky, C., in 1999 in a paper entitled "Glutamate mutase from Clostridium cochlearium: the structure of a coenzyme B12-dependent enzyme provides new mechanistic insights." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (GLUTAMATE MUTASE).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (GLUTAMATE MUTASE) P80078 (1-137) (GMSS_CLOCO)search Clostridium cochleariumsearch 100% 137 100%
C PROTEIN (GLUTAMATE MUTASE) P80078 (1-137) (GMSS_CLOCO)search Clostridium cochleariumsearch 100% 137 100%
B PROTEIN (GLUTAMATE MUTASE) P80077 (1-483) (GLME_CLOCO)search Clostridium cochleariumsearch 100% 483 100%
D PROTEIN (GLUTAMATE MUTASE) P80077 (1-483) (GLME_CLOCO)search Clostridium cochleariumsearch 100% 483 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P80078 (1 - 137) PROTEIN (GLUTAMATE MUTASE) Clostridium cochlearium
P80077 (1 - 483) PROTEIN (GLUTAMATE MUTASE) Clostridium cochlearium

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P80078) Cobalamin (vitamin B12)-binding domainsearch Rossmann foldsearch PF02310: B12 binding domainsearch
B, D (P80077) Glutamate mutase, large subunitsearch TIM Barrelsearch, Glutamate mutase, C-terminal domainsearch PF06368: Methylaspartate mutase E chain (MutE)search

Chain ID Molecular function (GO) Biological process (GO)
A, C (P80078) metal ion bindingsearch protein bindingsearch cobalamin bindingsearch intramolecular transferase activitysearch isomerase activitysearch methylaspartate mutase activitysearch glutamate catabolic process via L-citramalatesearch anaerobic glutamate catabolic processsearch
B, D (P80077) cobalamin bindingsearch isomerase activitysearch protein bindingsearch intramolecular transferase activitysearch catalytic activitysearch methylaspartate mutase activitysearch anaerobic glutamate catabolic processsearch metabolic processsearch glutamate catabolic process via L-citramalatesearch

Chain InterPro annotation
A, C Cobalamin (vitamin B12)-binding domainsearch Methylaspartate mutase S subunitsearch
B, D Glutamate mutase, E subunitsearch Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomainsearch Glutamate mutase E subunit, C-terminal domainsearch Cobalamin (vitamin B12)-dependent enzyme, catalyticsearch