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GLUTAMATE MUTASE FROM CLOSTRIDIUM COCHLEARIUM RECONSTITUTED WITH METHYL-COBALAMIN

Source organism: Clostridium cochlearium
Biochemical function: methylaspartate mutase activity
Biological process: anaerobic glutamate catabolic process
Cellular component: not assigned

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EC 5.4.99.1: Methylaspartate mutase

Reaction catalysed:
L-threo-3-methylaspartate = L-glutamate
Systematic name:
L-threo-3-methylaspartate carboxy-aminomethylmutase
Alternative Name(s):
  • B-methylaspartate-glutamate mutase
  • Beta-methylaspartate-glutamate mutase
  • Glutamate isomerase
  • Glutamate mutase
  • Glutamic acid isomerase
  • Glutamic acid mutase
  • Glutamic isomerase
  • Glutamic mutase
  • Methylaspartic acid mutase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF06368
Domain description: Methylaspartate mutase E chain (MutE)
Occurring in:
  1. Glutamate mutase epsilon subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of Pfam domain PF06368 (Methylaspartate mutase E chain (MutE)) in Glutamate mutase epsilon subunit. Showing 1 copy in chain B.

PF02310
Domain description: B12 binding domain
Occurring in:
  1. Glutamate mutase sigma subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of Pfam domain PF02310 (B12 binding domain) in Glutamate mutase sigma subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006396
Domain description: Glutamate mutase epsilon subunit
Occurring in:
  1. Glutamate mutase epsilon subunit
IPR006394
Domain description: Glutamate mutase sigma subunit
Occurring in:
  1. Glutamate mutase sigma subunit
IPR006158
Domain description: Cobalamin (vitamin B12)-binding domain
Occurring in:
  1. Glutamate mutase sigma subunit
IPR014714
Domain description: Glutamate mutase E subunit, C-terminal domain superfamily
Occurring in:
  1. Glutamate mutase epsilon subunit
IPR016176
Domain description: Cobalamin (vitamin B12)-dependent enzyme, catalytic
Occurring in:
  1. Glutamate mutase epsilon subunit
IPR036724
Domain description: Cobalamin-binding domain superfamily
Occurring in:
  1. Glutamate mutase sigma subunit

Structure domains

CATH CATH domains
3.90.970.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Glutamate mutase, C-terminal domain
Homology: Glutamate mutase, C-terminal domain
Occurring in:
  1. Glutamate mutase epsilon subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of CATH domain 3.90.970.10 (Glutamate mutase, C-terminal domain) in Glutamate mutase epsilon subunit. Showing 1 copy in chain B.
3.20.20.240
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Methylmalonyl-CoA mutase
Occurring in:
  1. Glutamate mutase epsilon subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of CATH domain 3.20.20.240 (TIM Barrel) in Glutamate mutase epsilon subunit. Showing 1 copy in chain B.
3.40.50.280
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Cobalamin-binding domain
Occurring in:
  1. Glutamate mutase sigma subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of CATH domain 3.40.50.280 (Rossmann fold) in Glutamate mutase sigma subunit. Showing 1 copy in chain A.
SCOP SCOP annotations
51707
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Cobalamin (vitamin B12)-dependent enzymes
Occurring in:
  1. Glutamate mutase epsilon subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of SCOP domain 51707 (Glutamate mutase, large subunit) in Glutamate mutase epsilon subunit. Showing 1 copy in chain B.
52243
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Cobalamin (vitamin B12)-binding domain
Occurring in:
  1. Glutamate mutase sigma subunit
The deposited structure of PDB entry 1cb7 contains 2 copies of SCOP domain 52243 (Cobalamin (vitamin B12)-binding domain) in Glutamate mutase sigma subunit. Showing 1 copy in chain A.

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