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STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II

The structure was published by Xue, Y., Liljas, A., Jonsson, B.H., and Lindskog, S., in 1993 in a paper entitled "Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch apical part of cellsearch microvillussearch membranesearch axonsearch plasma membranesearch myelin sheathsearch basolateral plasma membranesearch extracellular spacesearch positive regulation of bone resorptionsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch secretionsearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch response to pHsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch response to organic substancesearch response to zinc ionsearch response to estrogensearch kidney developmentsearch regulation of anion transportsearch response to steroid hormonesearch zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch