1caj Summary

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STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II

The structure was published by Xue, Y., Liljas, A., Jonsson, B.H., and Lindskog, S., in 1993 in a paper entitled "Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) plasma membranesearch cytoplasmsearch cytosolsearch extracellular spacesearch extracellular vesicular exosomesearch microvillussearch apical part of cellsearch axonsearch membranesearch basolateral plasma membranesearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch response to zinc ionsearch bicarbonate transportsearch secretionsearch regulation of anion transportsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch positive regulation of cellular pH reductionsearch response to organic substancesearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch carbon dioxide transportsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to estrogensearch angiotensin-activated signaling pathwaysearch kidney developmentsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch