1cai Summary



The structure was published by Xue, Y., Liljas, A., Jonsson, B.H., and Lindskog, S., in 1993 in a paper entitled "Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch cytosolsearch apical part of cellsearch extracellular vesicular exosomesearch microvillussearch plasma membranesearch extracellular spacesearch basolateral plasma membranesearch membranesearch axonsearch myelin sheathsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch response to steroid hormonesearch regulation of anion transportsearch regulation of intracellular pHsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch secretionsearch positive regulation of bone resorptionsearch response to pHsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch cellular response to fluid shear stresssearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch zinc ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch