1cah Summary



The structure was published by Hakansson, K. and Wehnert, A., in 1992 in a paper entitled "Structure of cobalt carbonic anhydrase complexed with bicarbonate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.88 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch cytosolsearch plasma membranesearch apical part of cellsearch extracellular vesicular exosomesearch axonsearch basolateral plasma membranesearch myelin sheathsearch extracellular spacesearch membranesearch microvillussearch positive regulation of bone resorptionsearch bicarbonate transportsearch response to estrogensearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch one-carbon metabolic processsearch response to zinc ionsearch kidney developmentsearch response to pHsearch regulation of anion transportsearch small molecule metabolic processsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch