1ca9 Summary

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STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A PEPTIDE FROM TNF-R2

The structure was published by Park, Y.C., Burkitt, V., Villa, A.R., Tong, L., and Wu, H., in 1999 in a paper entitled "Structural basis for self-association and receptor recognition of human TRAF2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) and PROTEIN (TNF-R2).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
B PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
C PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
D PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
E PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
F PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Q12933 (310-501) (TRAF2_HUMAN)search Homo sapienssearch < 90% 192 99%
G PROTEIN (TNF-R2) P20333 (420-428) (TNR1B_HUMAN)search Homo sapienssearch < 90% 10 100%
H PROTEIN (TNF-R2) P20333 (420-428) (TNR1B_HUMAN)search Homo sapienssearch < 90% 10 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q12933 (310 - 501) PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) Homo sapiens
P20333 (420 - 428) PROTEIN (TNF-R2)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F MATH domainsearch, Trimerization domain of TRAFsearch Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain Asearch MATH domainsearch
G, H

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D, E, F (Q12933) regulation of apoptotic processsearch regulation of JNK cascadesearch protein autoubiquitinationsearch activation of NF-kappaB-inducing kinase activitysearch tumor necrosis factor-mediated signaling pathwaysearch ubiquitin-protein transferase activitysearch

Chain InterPro annotation
A, B, C, D, E, F MATHsearch TRAF-likesearch TNF receptor-associated factor 2search
G, H