1ca2 Summary


PDB entry 1ca2 (supersedes 1cac)


The structure was published by Eriksson, A.E., Jones, T.A., and Liljas, A., in 1988 in a paper entitled "Refined structure of human carbonic anhydrase II at 2.0 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch regulation of intracellular pHsearch small molecule metabolic processsearch bicarbonate transportsearch kidney developmentsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch secretionsearch response to pHsearch response to estrogensearch response to organic substancesearch basolateral plasma membranesearch plasma membranesearch microvillussearch cytoplasmsearch extracellular vesicular exosomesearch cytosolsearch axonsearch myelin sheathsearch apical part of cellsearch extracellular spacesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch