1ca0 Summary

pdbe.org/1ca0
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BOVINE CHYMOTRYPSIN COMPLEXED TO APPI

The structure was published by Scheidig, A.J., Hynes, T.R., Pelletier, L.A., Wells, J.A., and Kossiakoff, A.A., in 1997 in a paper entitled "Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This entry contains 15 copies of 4 unique biopolymers (complete list).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BOVINE CHYMOTRYPSIN P00766 (1-13) (CTRA_BOVIN)search Bos taurussearch 94% 13 84%
F BOVINE CHYMOTRYPSIN P00766 (1-13) (CTRA_BOVIN)search Bos taurussearch 94% 13 84%
B BOVINE CHYMOTRYPSIN P00766 (16-146) (CTRA_BOVIN)search Bos taurussearch 94% 131 100%
G BOVINE CHYMOTRYPSIN P00766 (16-146) (CTRA_BOVIN)search Bos taurussearch 94% 131 100%
C BOVINE CHYMOTRYPSIN P00766 (149-245) (CTRA_BOVIN)search Bos taurussearch 94% 97 100%
H BOVINE CHYMOTRYPSIN P00766 (149-245) (CTRA_BOVIN)search Bos taurussearch 94% 97 100%
D PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR P05067 (289-342) (A4_HUMAN)search Homo sapienssearch < 90% 54 100%
I PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR P05067 (289-342) (A4_HUMAN)search Homo sapienssearch < 90% 54 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00766 (1 - 13) BOVINE CHYMOTRYPSIN Bos taurus
P05067 (289 - 342) PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, F (P00766) Eukaryotic proteasessearch
B, G (P00766) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
C, H (P00766) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
D, I Small Kunitz-type inhibitors & BPTI-like toxinssearch Factor Xa Inhibitorsearch Kunitz/Bovine pancreatic trypsin inhibitor domainsearch

Chain ID Biological process (GO) Molecular function (GO)
B, G (P00766) proteolysissearch serine-type endopeptidase activitysearch catalytic activitysearch
C, H (P00766) proteolysissearch catalytic activitysearch serine-type endopeptidase activitysearch
D, I (P05067) nervous system developmentsearch serine-type endopeptidase inhibitor activitysearch

Chain InterPro annotation
A, F
B, G Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
C, H Peptidase S1search Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
D, I Proteinase inhibitor I2, Kunitz metazoasearch Proteinase inhibitor I2, Kunitz, conserved sitesearch