1c96 Summary



The structure was published by Lloyd, S.J., Lauble, H., Prasad, G.S., and Stout, C.D., in 1999 in a paper entitled "The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.81 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of MITOCHONDRIAL ACONITASE. This molecule has the UniProt identifier P20004 (ACON_BOVIN)search. The sample contained 753 residues which is 96% of the natural sequence. Out of 753 residues 753 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOCHONDRIAL ACONITASE P20004 (29-779) (ACON_BOVIN)search Bos taurussearch 96% 753 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P20004 (29 - 779) MITOCHONDRIAL ACONITASE Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P20004) LeuD-likesearch, Aconitase iron-sulfur domainsearch Aconitase, domain 3search, Aconitase, Domain 2search, Aconitase, domain 4search PF00330: Aconitase family (aconitate hydratase)search, PF00694: Aconitase C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P20004) aconitate hydratase activitysearch 4 iron, 4 sulfur cluster bindingsearch iron ion bindingsearch lyase activitysearch iron-sulfur cluster bindingsearch metal ion bindingsearch tricarboxylic acid cyclesearch metabolic processsearch citrate metabolic processsearch mitochondrionsearch nucleussearch

Chain InterPro annotation
A Aconitase A/isopropylmalate dehydratase small subunit, swivelsearch Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alphasearch Aconitase, mitochondrial-likesearch Aconitase/3-isopropylmalate dehydratase, swivelsearch Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3search Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2search Aconitase/isopropylmalate dehydratasesearch Aconitase family, 4Fe-4S cluster binding sitesearch