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MECHANISM OF HYALURONAN BINDING AND DEGRADATION: STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE IN COMPLEX WITH HYALURONIC ACID DISACCHARIDE AT 1.7 A RESOLUTION

Source organism: Streptococcus pneumoniae
Biochemical function: carbohydrate binding
Biological process: carbohydrate metabolic process
Cellular component: extracellular region

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EC 4.2.2.1: Hyaluronate lyase

Reaction catalysed:
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
Systematic name:
Hyaluronate lyase
Alternative Name(s):
  • Glucuronoglycosaminoglycan lyase
  • Hyaluronidase
  • Mucinase
  • Spreading factor

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02884
Domain description: Polysaccharide lyase family 8, C-terminal beta-sandwich domain
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of Pfam domain PF02884 (Polysaccharide lyase family 8, C-terminal beta-sandwich domain) in Hyaluronate lyase. Showing 1 copy in chain A.

PF02278
Domain description: Polysaccharide lyase family 8, super-sandwich domain
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of Pfam domain PF02278 (Polysaccharide lyase family 8, super-sandwich domain) in Hyaluronate lyase. Showing 1 copy in chain A.

PF08124
Domain description: Polysaccharide lyase family 8, N terminal alpha-helical domain
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of Pfam domain PF08124 (Polysaccharide lyase family 8, N terminal alpha-helical domain) in Hyaluronate lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011071
Domain description: Polysaccharide lyase family 8-like, C-terminal
Occurring in:
  1. Hyaluronate lyase
IPR008929
Domain description: Chondroitin AC/alginate lyase
Occurring in:
  1. Hyaluronate lyase
IPR004103
Domain description: Polysaccharide lyase family 8, C-terminal
Occurring in:
  1. Hyaluronate lyase
IPR014718
Domain description: Glycoside hydrolase-type carbohydrate-binding
Occurring in:
  1. Hyaluronate lyase
IPR003159
Domain description: Polysaccharide lyase family 8, central domain
Occurring in:
  1. Hyaluronate lyase
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Hyaluronate lyase
IPR012970
Domain description: Polysaccharide lyase 8, N-terminal alpha-helical
Occurring in:
  1. Hyaluronate lyase
IPR038970
Domain description: Polysaccharide lyase 8
Occurring in:
  1. Hyaluronate lyase

Structure domains

CATH CATH domains
2.60.220.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Chondroitinase Ac; Chain A, domain 3
Homology: Polysaccharide lyase family 8-like, C-terminal
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of CATH domain 2.60.220.10 (Chondroitinase Ac; Chain A, domain 3) in Hyaluronate lyase. Showing 1 copy in chain A.
2.70.98.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Beta-galactosidase; Chain A, domain 5
Homology: Beta-galactosidase; Chain A, domain 5
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of CATH domain 2.70.98.10 (Beta-galactosidase; Chain A, domain 5) in Hyaluronate lyase. Showing 1 copy in chain A.
1.50.10.100
Class: Mainly Alpha
Architecture: Alpha/alpha barrel
Topology: Glycosyltransferase
Homology: Chondroitin AC/alginate lyase
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of CATH domain 1.50.10.100 (Glycosyltransferase) in Hyaluronate lyase. Showing 1 copy in chain A.
SCOP SCOP annotations
49864
Class: All beta proteins
Fold: Hyaluronate lyase-like, C-terminal domain
Superfamily: Hyaluronate lyase-like, C-terminal domain
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of SCOP domain 49864 (Hyaluronate lyase-like, C-terminal domain) in Hyaluronate lyase. Showing 1 copy in chain A.
50006
Class: All beta proteins
Fold: Supersandwich
Superfamily: Galactose mutarotase-like
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of SCOP domain 50006 (Hyaluronate lyase-like, central domain) in Hyaluronate lyase. Showing 1 copy in chain A.
48234
Class: All alpha proteins
Fold: alpha/alpha toroid
Superfamily: Chondroitin AC/alginate lyase
Occurring in:
  1. Hyaluronate lyase
The deposited structure of PDB entry 1c82 contains 1 copy of SCOP domain 48234 (Hyaluronate lyase-like catalytic, N-terminal domain) in Hyaluronate lyase. Showing 1 copy in chain A.

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