1c7d Summary

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DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 284 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch small molecule metabolic processsearch bicarbonate transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch
B, D (P68871) extracellular regionsearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch hemoglobin bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch metal ion bindingsearch oxygen transportsearch small molecule metabolic processsearch regulation of blood vessel sizesearch bicarbonate transportsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch receptor-mediated endocytosissearch platelet aggregationsearch regulation of blood pressuresearch renal absorptionsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch response to hydrogen peroxidesearch nitric oxide transportsearch transportsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch