1c7d Summary

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DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 284 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxidation-reduction processsearch positive regulation of cell deathsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch membranesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch
B, D (P68871) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch oxidation-reduction processsearch transportsearch regulation of blood pressuresearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch blood coagulationsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hemoglobin complexsearch extracellular regionsearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch