1c7d Summary

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DEOXY RHB1.2 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 284 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) iron ion bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch heme bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen bindingsearch oxygen transportsearch small molecule metabolic processsearch transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch
B, D (P68871) oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch peroxidase activitysearch haptoglobin bindingsearch heme bindingsearch small molecule metabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch oxygen transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch regulation of blood pressuresearch renal absorptionsearch blood coagulationsearch protein heterooligomerizationsearch transportsearch nitric oxide transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch