1c7c Summary

pdbe.org/1c7c
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DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 283 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P69905) oxygen transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch bicarbonate transportsearch receptor-mediated endocytosissearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch protein heterooligomerizationsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch
B, D (P68871) positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch platelet aggregationsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch blood coagulationsearch regulation of blood pressuresearch receptor-mediated endocytosissearch regulation of blood vessel sizesearch oxygen transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch nitric oxide transportsearch transportsearch protein heterooligomerizationsearch haptoglobin bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch