1c7b Summary

pdbe.org/1c7b
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DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.803 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch membranesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch bicarbonate transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch small molecule metabolic processsearch transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch
B, D (P68871) protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch regulation of blood vessel sizesearch renal absorptionsearch positive regulation of cell deathsearch transportsearch small molecule metabolic processsearch oxygen transportsearch oxidation-reduction processsearch platelet aggregationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch nitric oxide transportsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch