1c7b Summary

pdbe.org/1c7b
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DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)

The structure was published by Brucker, E.A., in 2000 in a paper entitled "Genetically crosslinked hemoglobin: a structural study." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.803 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) and PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (DEOXYHEMOGLOBIN (ALPHA CHAIN)) Homo sapiens
P68871 (2 - 147) PROTEIN (DEOXYHEMOGLOBIN (BETA CHAIN)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch bicarbonate transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch iron ion bindingsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch extracellular vesicular exosomesearch membranesearch extracellular regionsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch
B, D (P68871) oxygen transportsearch regulation of blood vessel sizesearch bicarbonate transportsearch protein heterooligomerizationsearch platelet aggregationsearch blood coagulationsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch renal absorptionsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch small molecule metabolic processsearch transportsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch hemoglobin bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch