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EBI PDBe PDBeView

PDBe Entry: 1c4z view

STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY
Summary
Header LIGASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.6 Å, R-factor: 26.2%, Free R-factor: 29.0%, Spacegroup: P 21 21 21
Released 17/11/1999, deposition: 14/10/1999, last revision: 24/02/2009
Authors Huang, L.search; Kinnucan, E.search; Wang, G.search; Beaudenon, S.search; Howley, P.M.search; Huibregtse, J.M.search; Pavletich, N.P.search
Primary citation Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
SCIENCEsearch vol:286, pag:1321-1326 (1999) [PubMed ID 10558980 ]search
Keywords BILOBAL STRUCTUREsearch, ELONGATED SHAPEsearch, E3 UBIQUITIN LIGASEsearch, E2 UBIQUITIN CONJUGATING ENZYMEsearch
EC 6.3.2.19 ExPASy BRENDA search (D)
Organism Homo sapiens(human) 9606search(A B C D)
UniProt Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (Renal carcinoma antigen NY-REN-54) Q05086search (A B C)
Ubiquitin-conjugating enzyme E2 L3 (EC 6.3.2.19) (Ubiquitin-protein ligase L3) (Ubiquitin carrier protein L3) (UbcH7) (E2-F1) (L-UBC) P68036search (D)
Solvent A, B, C, D
Related entries 1ubq, 1d5f
Polymers
Id Name Type UniProt Residues Observed
A, B, C UBIQUITIN-PROTEIN LIGASE E3A Protein Q05086 (UBE3A_HUMAN)search
 358 97%
D UBIQUITIN CONJUGATING ENZYME E2 Protein P68036 (UB2L3_HUMAN)search
 154 93%
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