1c4u Summary



The structure was published by Krishnan, R., Mochalkin, I., Arni, R., and Tulinsky, A., in 2000 in a paper entitled "Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely thrombin and PROTEIN (HIRUGEN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
1 thrombin P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 83%
2 thrombin P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 97%
3 PROTEIN (HIRUGEN) P28504 (55-63) (HIR2_HIRME)search Hirudo medicinalissearch < 90% 14 57%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00734 (328 - 363) thrombin Homo sapiens
P28504 (55 - 63) PROTEIN (HIRUGEN)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
1 (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
2 (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
3 Hirudinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
1 (P00734) proteolysissearch blood coagulationsearch extracellular regionsearch serine-type endopeptidase activitysearch
2 (P00734) proteolysissearch blood coagulationsearch serine-type endopeptidase activitysearch calcium ion bindingsearch catalytic activitysearch

Chain InterPro annotation
1 Thrombin light chainsearch
2 Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch