Assemblies
Assembly Name:
alpha-thrombin complex and Hirudin-2
Multimeric state:
hetero trimer
Accessible surface area:
12411.97 Å2
Buried surface area:
4572.15 Å2
Dissociation area:
533.33
Å2
Dissociation energy (ΔGdiss):
-1.47
kcal/mol
Dissociation entropy (TΔSdiss):
7.07
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133087
Macromolecules
Chain: 1
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P00734 (Residues: 328-363; Coverage: 6%)
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases
Chain: 2
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Trypsin
InterPro:
SCOP: Eukaryotic proteases
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Pfam: Trypsin
InterPro:
- Serine proteases, trypsin domain
- Peptidase S1, PA clan
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Prothrombin/thrombin
- Serine proteases, trypsin family, serine active site
SCOP: Eukaryotic proteases
Chain: 3
Length: 14 amino acids
Theoretical weight: 1.65 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 14 amino acids
Theoretical weight: 1.65 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P28504 (Residues: 55-63; Coverage: 14%)
