1c3c Summary



The structure was published by Toth, E.A. and Yeates, T.O., in 2000 in a paper entitled "The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (ADENYLOSUCCINATE LYASE).

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (ADENYLOSUCCINATE LYASE) Q9X0I0 (2-430) (PUR8_THEMA)search Thermotoga maritima MSB8search 100% 429 98%
B PROTEIN (ADENYLOSUCCINATE LYASE) Q9X0I0 (2-430) (PUR8_THEMA)search Thermotoga maritima MSB8search 100% 429 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9X0I0 (2 - 430) PROTEIN (ADENYLOSUCCINATE LYASE) Thermotoga maritima

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q9X0I0) L-aspartase/fumarasesearch Fumarase/aspartase (N-terminal domain)search, Fumarase/aspartase (Central domain)search, Fumarase/aspartase (C-terminal domain)search PF00206: Lyasesearch, PF10397: Adenylosuccinate lyase C-terminussearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9X0I0) N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activitysearch catalytic activitysearch (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activitysearch lyase activitysearch purine nucleotide biosynthetic processsearch purine ribonucleotide biosynthetic processsearch 'de novo' IMP biosynthetic processsearch 'de novo' AMP biosynthetic processsearch

Chain InterPro annotation
A, B Fumarate lyase familysearch Adenylosuccinate lyasesearch L-Aspartase-likesearch Adenylosuccinate lyase C-terminalsearch Fumarate lyase, conserved sitesearch Fumarate lyase, N-terminalsearch Fumarase/histidase, N-terminalsearch