1c25 Summary



The structure was published by Fauman, E.B., Cogswell, J.P., Lovejoy, B., et al., Piwnica-Worms, H., Rink, M.J., and Saper, M.A., in 1998 in a paper entitled "Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CDC25A. This molecule has the UniProt identifier P30304 (MPIP1_HUMAN)search. The sample contained 161 residues which is < 90% of the natural sequence. Out of 161 residues 160 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CDC25A P30304 (337-496) (MPIP1_HUMAN)search Homo sapienssearch < 90% 161 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30304 (337 - 496) CDC25A Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Cell cycle control phosphatase, catalytic domainsearch Oxidized Rhodanese, domain 1search Rhodanese-like domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P30304) intracellularsearch protein dephosphorylationsearch mitotic M phasesearch protein tyrosine phosphatase activitysearch

Chain InterPro annotation
A M-phase inducer phosphatasesearch Rhodanese-like domainsearch