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HUMAN CDC25A CATALYTIC DOMAIN

Source organism: Homo sapiens
Biochemical function: protein tyrosine phosphatase activity
Biological process: positive regulation of cell cycle G2/M phase transition
Cellular component: not assigned

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EC 3.1.3.48: Protein-tyrosine-phosphatase

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Systematic name:
Protein-tyrosine-phosphate phosphohydrolase
Alternative Name(s):
  • (Phosphotyrosine)protein phosphatase
  • PPT-phosphatase
  • PTP-phosphatase
  • PTPase
  • Phosphoprotein phosphatase (phosphotyrosine)
  • Phosphotyrosine histone phosphatase
  • Phosphotyrosine phosphatase
  • Phosphotyrosine protein phosphatase
  • Phosphotyrosylprotein phosphatase
  • Protein phosphotyrosine phosphatase
  • Tyrosine O-phosphate phosphatase
  • Tyrosylprotein phosphatase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00581
Domain description: Rhodanese-like domain
Occurring in:
  1. M-phase inducer phosphatase 1
The deposited structure of PDB entry 1c25 contains 1 copy of Pfam domain PF00581 (Rhodanese-like domain) in M-phase inducer phosphatase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000751
Domain description: M-phase inducer phosphatase
Occurring in:
  1. M-phase inducer phosphatase 1
IPR001763
Domain description: Rhodanese-like domain
Occurring in:
  1. M-phase inducer phosphatase 1
IPR036873
Domain description: Rhodanese-like domain superfamily
Occurring in:
  1. M-phase inducer phosphatase 1

Structure domain

CATH CATH domain
3.40.250.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Oxidized Rhodanese; domain 1
Homology: Rhodanese-like domain
Occurring in:
  1. M-phase inducer phosphatase 1
The deposited structure of PDB entry 1c25 contains 1 copy of CATH domain 3.40.250.10 (Oxidized Rhodanese; domain 1) in M-phase inducer phosphatase 1. Showing 1 copy in chain A.
SCOP SCOP annotation
52822
Class: Alpha and beta proteins (a/b)
Fold: Rhodanese/Cell cycle control phosphatase
Superfamily: Rhodanese/Cell cycle control phosphatase
Occurring in:
  1. M-phase inducer phosphatase 1
The deposited structure of PDB entry 1c25 contains 1 copy of SCOP domain 52822 (Cell cycle control phosphatase, catalytic domain) in M-phase inducer phosphatase 1. Showing 1 copy in chain A.

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