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PDBe Entry: 1c0t 
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.7 Å, R-factor: 20.8%, Free R-factor: 27.6%, Spacegroup: P 21 21 21
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19/07/2000, deposition: 19/07/1999, last revision: 24/02/2009
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Ren, J.; Esnouf, R.M.; Hopkins, A.L.; Stuart, D.I.; Stammers, D.K.
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Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.MED.CHEM. vol:42, pag:3845-3851 (1999) [PubMed ID 10508433 ]
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HIV-1 REVERSE TRANSCRIPTASE, AIDS, NON-NUCLEOSIDE INHIBITOR, DRUG DESIGN, TRANSFERASE
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2.7.7.49 ExPASy BRENDA 2.7.7.7 ExPASy BRENDA 3.1.26.4 ExPASy BRENDA 3.4.23.16 ExPASy BRENDA (A B)
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Human immunodeficiency virus 1 11676(A B)
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Gag-Pol polyprotein (Pr160Gag-Pol) [Contains: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide p2; Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (Retropepsin) (PR); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p66 RT); p51 RT; p15; Integrase (IN)] P04585 (A B)
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A, B
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1rtv, 1rth, 1vru, 1rti, 1rtj, 1rev, 1rt1, 1rt2, 1klm, 1rt3, 1rt4, 1rt5, 1rt6, 1rt7, 1c0u
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| A |
HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN) |
Protein |
P04585 (POL_HV1H2)
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560 |
87% |
| B |
HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN) |
Protein |
P04585 (POL_HV1H2)
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440 |
84% |
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| A |
(R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE |
BM1
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