1bzz Summary

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HEMOGLOBIN (ALPHA V1M) MUTANT

The structure was published by Hui, H.L., Kavanaugh, J.S., Doyle, M.L., et al., Holt, J.M., Ackers, G.K., and Noble, R.W., in 1999 in a paper entitled "Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN ALPHA CHAIN) and PROTEIN (HEMOGLOBIN BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (3-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin complexsearch extracellular regionsearch membranesearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch cytosolsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch transportsearch oxygen transportsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch
B, D (P68871) heme bindingsearch protein bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch extracellular regionsearch hemoglobin complexsearch extracellular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch nitric oxide transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch regulation of blood vessel sizesearch renal absorptionsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch transportsearch receptor-mediated endocytosissearch oxidation-reduction processsearch blood coagulationsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch