1bzy Summary



The structure was published by Shi, W., Li, C.M., Tyler, P.C., et al., Grubmeyer, C., Schramm, V.L., and Almo, S.C., in 1999 in a paper entitled "The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
B HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
C HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
D HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P00492) Phosphoribosyltransferases (PRTases)search Rossmann foldsearch PF00156: Phosphoribosyl transferase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P00492) IMP salvagesearch positive regulation of dopamine metabolic processsearch central nervous system neuron developmentsearch purine ribonucleoside salvagesearch nucleoside metabolic processsearch dopamine metabolic processsearch purine nucleotide biosynthetic processsearch hypoxanthine salvagesearch striatum developmentsearch adenine salvagesearch cerebral cortex neuron differentiationsearch hypoxanthine metabolic processsearch protein homotetramerizationsearch guanine salvagesearch lymphocyte proliferationsearch cytolysissearch purine-containing compound salvagesearch small molecule metabolic processsearch GMP salvagesearch nucleobase-containing small molecule metabolic processsearch adenine metabolic processsearch GMP catabolic processsearch response to amphetaminesearch grooming behaviorsearch IMP metabolic processsearch dendrite morphogenesissearch purine nucleobase metabolic processsearch locomotory behaviorsearch cytoplasmsearch extracellular vesicular exosomesearch cytosolsearch hypoxanthine phosphoribosyltransferase activitysearch transferase activitysearch transferase activity, transferring glycosyl groupssearch guanine phosphoribosyltransferase activitysearch magnesium ion bindingsearch protein homodimerization activitysearch identical protein bindingsearch protein bindingsearch metal ion bindingsearch nucleotide bindingsearch

Chain InterPro annotation
A, B, C, D Phosphoribosyltransferase domainsearch Hypoxanthine phosphoribosyl transferasesearch Phosphoribosyltransferase-likesearch