1bzy Summary



The structure was published by Shi, W., Li, C.M., Tyler, P.C., et al., Grubmeyer, C., Schramm, V.L., and Almo, S.C., in 1999 in a paper entitled "The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
B HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
C HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%
D HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE P00492 (2-218) (HPRT_HUMAN)search Homo sapienssearch 98% 217 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P00492) Phosphoribosyltransferases (PRTases)search Rossmann foldsearch PF00156: Phosphoribosyl transferase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P00492) nucleoside metabolic processsearch hypoxanthine salvagesearch adenine salvagesearch hypoxanthine metabolic processsearch protein homotetramerizationsearch cerebral cortex neuron differentiationsearch dendrite morphogenesissearch purine nucleotide biosynthetic processsearch purine ribonucleoside salvagesearch nucleobase-containing small molecule metabolic processsearch grooming behaviorsearch purine-containing compound salvagesearch small molecule metabolic processsearch response to amphetaminesearch guanine salvagesearch GMP salvagesearch IMP metabolic processsearch central nervous system neuron developmentsearch dopamine metabolic processsearch purine nucleobase metabolic processsearch locomotory behaviorsearch adenine metabolic processsearch positive regulation of dopamine metabolic processsearch GMP catabolic processsearch IMP salvagesearch lymphocyte proliferationsearch cytolysissearch striatum developmentsearch cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch guanine phosphoribosyltransferase activitysearch hypoxanthine phosphoribosyltransferase activitysearch protein homodimerization activitysearch magnesium ion bindingsearch protein bindingsearch metal ion bindingsearch transferase activity, transferring glycosyl groupssearch nucleotide bindingsearch transferase activitysearch identical protein bindingsearch

Chain InterPro annotation
A, B, C, D Phosphoribosyltransferase domainsearch Hypoxanthine phosphoribosyl transferasesearch Phosphoribosyltransferase-likesearch