1bz1 Summary

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HEMOGLOBIN (ALPHA + MET) VARIANT

The structure was published by Hui, H.L., Kavanaugh, J.S., Doyle, M.L., et al., Holt, J.M., Ackers, G.K., and Noble, R.W., in 1999 in a paper entitled "Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN ALPHA CHAIN) and PROTEIN (HEMOGLOBIN BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 100%
C PROTEIN (HEMOGLOBIN ALPHA CHAIN) P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 100%
B PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D PROTEIN (HEMOGLOBIN BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (1 - 142) PROTEIN (HEMOGLOBIN ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch transportsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch cytosolic small ribosomal subunitsearch membranesearch
B, D (P68871) oxygen transportsearch oxidation-reduction processsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch renal absorptionsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch blood coagulationsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch transportsearch nitric oxide transportsearch small molecule metabolic processsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch hemoglobin bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch