1byg Summary

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KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE

The structure was published by Lamers, M.B., Antson, A.A., Hubbard, R.E., Scott, R.K., and Williams, D.H., in 1999 in a paper entitled "Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (C-TERMINAL SRC KINASE). This molecule has the UniProt identifier P41240 (CSK_HUMAN)search. The sample contained 278 residues which is < 90% of the natural sequence. Out of 278 residues 246 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (C-TERMINAL SRC KINASE) P41240 (173-450) (CSK_HUMAN)search Homo sapienssearch < 90% 278 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41240 (173 - 450) PROTEIN (C-TERMINAL SRC KINASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P41240) transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch ATP bindingsearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch