1by4 Summary

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STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA

The structure was published by Zhao, Q., Chasse, S.A., Devarakonda, S., Sierk, M.L., Ahvazi, B., and Rastinejad, F., in 2000 in a paper entitled "Structural basis of RXR-DNA interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*C*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*A)-3'), and PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA) P19793 (129-209) (RXRA_HUMAN)search Homo sapienssearch 98% 82 100%
B PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA) P19793 (129-209) (RXRA_HUMAN)search Homo sapienssearch 98% 82 100%
C PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA) P19793 (129-209) (RXRA_HUMAN)search Homo sapienssearch 98% 82 100%
D PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA) P19793 (129-209) (RXRA_HUMAN)search Homo sapienssearch 98% 82 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19793 (129 - 209) PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P19793) Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch PF00105: Zinc finger, C4 type (two domains)search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D (P19793) nucleussearch sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B, C, D Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch