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PDBe Entry: 1bxo 
ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE
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HYDROLASE
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X-RAY DIFFRACTION
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Resolution: 0.95 Å, R-factor: 10.04%, Free R-factor: 12.47%, Spacegroup: C 1 2 1
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14/10/1998, deposition: 07/10/1998, last revision: 24/02/2009
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Khan, A.R.; Parrish, J.C.; Fraser, M.E.; Smith, W.W.; Bartlett, P.A.; James, M.N.G.
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Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes.
BIOCHEMISTRY vol:37, pag:16839-16845 (1998) [PubMed ID 9836576 ]
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HYDROLASE, PHOSPHONATE INHIBITORS, MACROCYCLE
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3.4.23.20 ExPASy BRENDA (A)
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Penicillium janthinellum 5079(A)
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Penicillopepsin (EC 3.4.23.20) (Peptidase A) P00798 (A)
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A
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| A |
PROTEIN (PENICILLOPEPSIN) |
Protein |
P00798 (PENP_PENJA)
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323 |
100% |
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| A |
SUGAR (ALPHA-D-MANNOSE) |
MAN
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| A |
SULFATE ION |
SO4
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| A |
METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUTYL]HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL)PHENYLPROPANOATE |
PP7
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| A |
GLYCEROL |
GOL
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