1bx2 Summary

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CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN

The structure was published by Smith, K.J., Pyrdol, J., Gauthier, L., Wiley, D.C., and Wucherpfennig, K.W., in 1998 in a paper entitled "Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely PROTEIN (HLA-DR2).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HLA-DR2) P01903 (27-206) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
D PROTEIN (HLA-DR2) P01903 (27-206) (DRA_HUMAN)search Homo sapienssearch < 90% 180 100%
B PROTEIN (HLA-DR2) P01911 (32-222) (2B1F_HUMAN)search Homo sapienssearch < 90% 191 100%
E PROTEIN (HLA-DR2) P01911 (32-222) (2B1F_HUMAN)search Homo sapienssearch < 90% 191 100%
C PROTEIN (HLA-DR2) P02686 (217-231) (MBP_HUMAN)search Homo sapienssearch < 90% 15 93%
F PROTEIN (HLA-DR2) P02686 (217-231) (MBP_HUMAN)search Homo sapienssearch < 90% 15 93%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (27 - 206) PROTEIN (HLA-DR2) Homo sapiens
P01911 (32 - 222) PROTEIN (HLA-DR2) Homo sapiens
P02686 (217 - 231) PROTEIN (HLA-DR2) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, E C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, F Myelin basic proteinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, D (P01903) immune responsesearch antigen processing and presentationsearch MHC class II protein complexsearch membranesearch
B, E (P01911) antigen processing and presentationsearch immune responsesearch MHC class II protein complexsearch membranesearch
C, F (P02686) structural constituent of myelin sheathsearch

Chain InterPro annotation
A, D MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, E MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, F Myelin basic proteinsearch