1buw Summary

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CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A

The structure was published by Chan, N.L., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "Crystal structure of the S-nitroso form of liganded human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%
D PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch transportsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch small molecule metabolic processsearch protein bindingsearch peroxidase activitysearch iron ion bindingsearch oxygen transporter activitysearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch haptoglobin bindingsearch cytosolic small ribosomal subunitsearch extracellular regionsearch cytosolsearch membranesearch blood microparticlesearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch
B, D (P68871) oxygen transportsearch blood coagulationsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch transportsearch regulation of blood pressuresearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch oxidation-reduction processsearch receptor-mediated endocytosissearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch positive regulation of cell deathsearch nitric oxide transportsearch protein heterooligomerizationsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch