1buw Summary

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CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A

The structure was published by Chan, N.L., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "Crystal structure of the S-nitroso form of liganded human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%
D PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch oxidation-reduction processsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch protein bindingsearch iron ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) oxygen transportsearch blood coagulationsearch renal absorptionsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch regulation of blood pressuresearch response to hydrogen peroxidesearch nitric oxide transportsearch protein heterooligomerizationsearch platelet aggregationsearch transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch small molecule metabolic processsearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin bindingsearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch