1buw Summary

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CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A

The structure was published by Chan, N.L., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "Crystal structure of the S-nitroso form of liganded human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%
D PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch small molecule metabolic processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch extracellular regionsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch
B, D (P68871) oxygen transportsearch blood coagulationsearch renal absorptionsearch protein heterooligomerizationsearch bicarbonate transportsearch nitric oxide transportsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch regulation of blood pressuresearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch