1buw Summary

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CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A

The structure was published by Chan, N.L., Rogers, P.H., and Arnone, A., in 1998 in a paper entitled "Crystal structure of the S-nitroso form of liganded human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (HEMOGLOBIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C PROTEIN (HEMOGLOBIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%
D PROTEIN (HEMOGLOBIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) PROTEIN (HEMOGLOBIN) Homo sapiens
P68871 (2 - 147) PROTEIN (HEMOGLOBIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch
B, D (P68871) oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transportsearch blood coagulationsearch renal absorptionsearch transportsearch bicarbonate transportsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch positive regulation of cell deathsearch platelet aggregationsearch protein heterooligomerizationsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch small molecule metabolic processsearch regulation of blood pressuresearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch