› 1btg

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF BETA NERVE GROWTH FACTOR AT 2.5 A RESOLUTION IN C2 SPACE GROUP WITH ZN IONS BOUND

Released:
DOI: 10.2210/pdb1btg/pdb
PDB entry 1btg coloured by chain, front view.
PDB entry 1btg coloured by chain, side view.
PDB entry 1btg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites.
Holland DR, Cousens LS, Meng W, Matthews BW
J. Mol. Biol. 239 385-400 (1994)
PMID: 8201620

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-nerve growth factor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 110 amino acids
Theoretical weight: 12.38 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P01139 (Residues: 130-239; Coverage: 49%)
Gene names: Ngf, Ngfb
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 109.8Å b: 93.9Å c: 58.9Å
α: 90° β: 123.1° γ: 90°
R-values:
R R work R free
0.179 not available not available
Expression system: Not provided

Quick links

Citations

6 review citations

Zinc metabolism in the brain: relevance to human neurodegenerative disorders.
Cuajungco et al. (1997)
5 more

12 mentions without citation

The nerve of ovulation-inducing factor in semen.
Ratto et al. (2012)
11 more