1bsx Summary

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STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS

The structure was published by Darimont, B.D., Wagner, R.L., Apriletti, J.W., et al., Baxter, J.D., Fletterick, R.J., and Yamamoto, K.R., in 1998 in a paper entitled "Structure and specificity of nuclear receptor-coactivator interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.7 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (THYROID HORMONE RECEPTOR BETA) and PROTEIN (GRIP1).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (THYROID HORMONE RECEPTOR BETA) P10828 (202-461) (THB_HUMAN)search Homo sapienssearch < 90% 260 93%
B PROTEIN (THYROID HORMONE RECEPTOR BETA) P10828 (202-461) (THB_HUMAN)search Homo sapienssearch < 90% 260 93%
X PROTEIN (GRIP1) Not available
Not available Not available 13 92%
Y PROTEIN (GRIP1) Not available
Not available Not available 13 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10828 (202 - 461) PROTEIN (THYROID HORMONE RECEPTOR BETA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
X, Y

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P10828) regulation of transcription, DNA-dependentsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
X, Y Nuclear receptor coactivator Src-1search