 |
PDBe Entry: 1brc 
RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Chain E (Protein)
| 1 |
I |
V |
G |
G |
Y |
T |
C |
Q |
E |
N |
|
S |
V |
P |
Y |
Q |
V |
S |
L |
N |
S |
|
G |
Y |
H |
F |
C |
G |
G |
S |
L |
I |
|
N |
D |
Q |
W |
V |
V |
S |
A |
A |
H |
|
C |
Y |
K |
S |
R |
I |
Q |
V |
R |
L |
|
G |
E |
H |
N |
I |
N |
V |
L |
E |
G |
|
ILE |
VAL |
GLY |
GLY |
TYR |
THR |
CYS |
GLN |
GLU |
ASN |
|
SER |
VAL |
PRO |
TYR |
GLN |
VAL |
SER |
LEU |
ASN |
SER |
|
GLY |
TYR |
HIS |
PHE |
CYS |
GLY |
GLY |
SER |
LEU |
ILE |
|
ASN |
ASP |
GLN |
TRP |
VAL |
VAL |
SER |
ALA |
ALA |
HIS |
|
CYS |
TYR |
LYS |
SER |
ARG |
ILE |
GLN |
VAL |
ARG |
LEU |
|
GLY |
GLU |
HIS |
ASN |
ILE |
ASN |
VAL |
LEU |
GLU |
GLY |
|
I |
V |
G |
G |
Y |
T |
C |
Q |
E |
N |
|
S |
V |
P |
Y |
Q |
V |
S |
L |
N |
S |
|
G |
Y |
H |
F |
C |
G |
G |
S |
L |
I |
|
N |
D |
Q |
W |
V |
V |
S |
A |
A |
H |
|
C |
Y |
K |
S |
R |
I |
Q |
V |
R |
L |
|
G |
E |
H |
N |
I |
N |
V |
L |
E |
G |
|
24
|
|
| |
|
|
|
|
|
| | | | | | | | | | | | | | | | | | | | |
|
|
| 61 |
N |
E |
Q |
F |
V |
N |
A |
A |
K |
I |
|
I |
K |
H |
P |
N |
F |
D |
R |
K |
T |
|
L |
N |
N |
D |
I |
M |
L |
I |
K |
L |
|
S |
S |
P |
V |
K |
L |
N |
A |
R |
V |
|
A |
T |
V |
A |
L |
P |
S |
S |
C |
A |
|
P |
A |
G |
T |
Q |
C |
L |
I |
S |
G |
|
ASN |
GLU |
GLN |
PHE |
VAL |
ASN |
ALA |
ALA |
LYS |
ILE |
|
ILE |
LYS |
HIS |
PRO |
ASN |
PHE |
ASP |
ARG |
LYS |
THR |
|
LEU |
ASN |
ASN |
ASP |
ILE |
MET |
LEU |
ILE |
LYS |
LEU |
|
SER |
SER |
PRO |
VAL |
LYS |
LEU |
ASN |
ALA |
ARG |
VAL |
|
ALA |
THR |
VAL |
ALA |
LEU |
PRO |
SER |
SER |
CYS |
ALA |
|
PRO |
ALA |
GLY |
THR |
GLN |
CYS |
LEU |
ILE |
SER |
GLY |
|
N |
E |
Q |
F |
V |
N |
A |
A |
K |
I |
|
I |
K |
H |
P |
N |
F |
D |
R |
K |
T |
|
L |
N |
N |
D |
I |
M |
L |
I |
K |
L |
|
S |
S |
P |
V |
K |
L |
N |
A |
R |
V |
|
A |
T |
V |
A |
L |
P |
S |
S |
C |
A |
|
P |
A |
G |
T |
Q |
C |
L |
I |
S |
G |
|
|
|
| |
|
|
|
|
|
| | | | | | | | | | |
|
|
| 121 |
W |
G |
N |
T |
L |
S |
S |
G |
V |
N |
|
E |
P |
D |
L |
L |
Q |
C |
L |
D |
A |
|
P |
L |
L |
P |
Q |
A |
D |
C |
E |
A |
|
S |
Y |
P |
G |
K |
I |
T |
D |
N |
M |
|
V |
C |
V |
G |
F |
L |
E |
G |
G |
K |
|
G |
S |
C |
Q |
G |
D |
S |
G |
G |
P |
|
TRP |
GLY |
ASN |
THR |
LEU |
SER |
SER |
GLY |
VAL |
ASN |
|
GLU |
PRO |
ASP |
LEU |
LEU |
GLN |
CYS |
LEU |
ASP |
ALA |
|
PRO |
LEU |
LEU |
PRO |
GLN |
ALA |
ASP |
CYS |
GLU |
ALA |
|
SER |
TYR |
PRO |
GLY |
LYS |
ILE |
THR |
ASP |
ASN |
MET |
|
VAL |
CYS |
VAL |
GLY |
PHE |
LEU |
GLU |
GLY |
GLY |
LYS |
|
GLY |
SER |
CYS |
GLN |
GLY |
ASP |
SER |
GLY |
GLY |
PRO |
|
W |
G |
N |
T |
L |
S |
S |
G |
V |
N |
|
E |
P |
D |
L |
L |
Q |
C |
L |
D |
A |
|
P |
L |
L |
P |
Q |
A |
D |
C |
E |
A |
|
S |
Y |
P |
G |
K |
I |
T |
D |
N |
M |
|
V |
C |
V |
G |
F |
L |
E |
G |
G |
K |
|
D |
S |
C |
Q |
G |
D |
S |
G |
G |
P |
|
|
|
|
|
|
|
|
|
| | | | | | | | | | | | | | | | | | | | | | |
|
|
| 181 |
V |
V |
C |
N |
G |
E |
L |
Q |
G |
I |
|
V |
S |
W |
G |
Y |
G |
C |
A |
L |
P |
|
D |
N |
P |
D |
V |
Y |
T |
K |
V |
C |
|
N |
Y |
V |
D |
W |
I |
Q |
D |
T |
I |
|
A |
A |
N |
|
VAL |
VAL |
CYS |
ASN |
GLY |
GLU |
LEU |
GLN |
GLY |
ILE |
|
VAL |
SER |
TRP |
GLY |
TYR |
GLY |
CYS |
ALA |
LEU |
PRO |
|
ASP |
ASN |
PRO |
ASP |
VAL |
TYR |
THR |
LYS |
VAL |
CYS |
|
ASN |
TYR |
VAL |
ASP |
TRP |
ILE |
GLN |
ASP |
THR |
ILE |
|
ALA |
ALA |
ASN |
|
V |
V |
C |
N |
G |
E |
L |
Q |
G |
I |
|
V |
S |
W |
G |
Y |
G |
C |
A |
L |
P |
|
D |
N |
P |
G |
V |
Y |
T |
K |
V |
C |
|
N |
Y |
V |
D |
W |
I |
Q |
D |
T |
I |
|
A |
A |
N |
|
246
|
|
| | |
|
| |
|
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| | | | | | | | | | | | | | |
|
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Regions
UniProt
P00763
24 .. 246 > 16 .. 245 (PDB)
Secondary structure
Loop
Strand
Helix
Uniprot features
| ACT_SITE, COMPBIAS, CONFLICT, DISULFID, METAL, MOD_RES, MUTAGEN, REGION, SITE, VAR_SEQ |
IVGGYTCQENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGNEQFVNAAKIIKHPNFDRKTLNNDIMLIKLSSPVKLNARVATVALPSSCAPAGTQCLISGWGNTLSSGVNEPDLLQCLDAPLLPQADCEASYPGKITDNMVCVGFLEGGKGSCQGDSGGPVVCNGELQGIVSWGYGCALPDNPDVYTKVCNYVDWIQDTIAAN
Chain I (Protein)
| 1 |
V |
R |
E |
V |
C |
S |
E |
Q |
A |
E |
|
T |
G |
P |
C |
R |
A |
M |
I |
S |
R |
|
W |
Y |
F |
D |
V |
T |
E |
G |
K |
C |
|
A |
P |
F |
F |
Y |
G |
G |
C |
G |
G |
|
N |
R |
N |
N |
F |
D |
T |
E |
E |
Y |
|
C |
M |
A |
V |
C |
G |
|
VAL |
ARG |
GLU |
VAL |
CYS |
SER |
GLU |
GLN |
ALA |
GLU |
|
THR |
GLY |
PRO |
CYS |
ARG |
ALA |
MET |
ILE |
SER |
ARG |
|
TRP |
TYR |
PHE |
ASP |
VAL |
THR |
GLU |
GLY |
LYS |
CYS |
|
ALA |
PRO |
PHE |
PHE |
TYR |
GLY |
GLY |
CYS |
GLY |
GLY |
|
ASN |
ARG |
ASN |
ASN |
PHE |
ASP |
THR |
GLU |
GLU |
TYR |
|
CYS |
MET |
ALA |
VAL |
CYS |
GLY |
|
V |
R |
E |
V |
C |
S |
E |
Q |
A |
E |
|
T |
G |
P |
C |
R |
A |
M |
I |
S |
R |
|
W |
Y |
F |
D |
V |
T |
E |
G |
K |
C |
|
A |
P |
F |
F |
Y |
G |
G |
C |
G |
G |
|
N |
R |
N |
N |
F |
D |
T |
E |
E |
Y |
|
C |
M |
A |
V |
C |
G |
|
287
342
|
|
|
|
| |
|
|
|
| | | | | | | | | | | | | | | | |
|
| |
Regions
UniProt
P05067
287 .. 342 > 1 .. 56 (PDB)
Secondary structure
Loop
Helix
Strand
Uniprot features
| ACT_SITE, COMPBIAS, CONFLICT, DISULFID, METAL, MOD_RES, MUTAGEN, REGION, SITE, VAR_SEQ |
VREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG
|