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EBI PDBe PDBeView

PDBe Entry: 1boz view

STRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4-DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 20.2%, Spacegroup: H 3
Released 12/08/1998, deposition: 06/08/1998, last revision: 24/02/2009
Authors Gangjee, A.search; Vidwans, A.P.search; Vasudevan, A.search; Queener, S.F.search; Kisliuk, R.L.search; Cody, V.search; Li, R.search; Galitsky, N.search; Luft, J.R.search; Pangborn, W.search
Primary citation Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
J.MED.CHEM.search vol:41, pag:3426-3434 (1998) [PubMed ID 9719595 ]search
Keywords OXIDOREDUCTASEsearch
EC 1.5.1.3 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Dihydrofolate reductase (EC 1.5.1.3) P00374search (A)
Solvent A
Polymers
Id Name Type UniProt Residues Observed
A PROTEIN (DIHYDROFOLATE REDUCTASE) Protein P00374 (DYR_HUMAN)search
 186 100%
Heterogens
Id Name Ligands
A NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE NDP search
A N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE PRD search
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