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PVUII DNA METHYLTRANSFERASE (CYTOSINE-N4-SPECIFIC)

The structure was published by Gong, W., O'Gara, M., Blumenthal, R.M., and Cheng, X., in 1997 in a paper entitled "Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II). This molecule has the UniProt identifier P11409 (MTP2_PROHU)search. The sample contained 323 residues which is 96% of the natural sequence. Out of 323 residues 275 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II) P11409 (14-336) (MTP2_PROHU)search Proteus hauserisearch 96% 323 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11409 (14 - 336) PROTEIN (N-4 CYTOSINE-SPECIFIC METHYLTRANSFERASE PVU II) Proteus vulgaris

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11409) Type II DNA methylasesearch Vaccinia Virus protein VP39search PF01555: DNA methylasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P11409) site-specific DNA-methyltransferase (cytosine-N4-specific) activitysearch N-methyltransferase activitysearch methyltransferase activitysearch transferase activitysearch DNA bindingsearch N-4 methylation of cytosinesearch DNA methylationsearch DNA restriction-modification systemsearch methylationsearch

Chain InterPro annotation
A Restriction/modification DNA-methylasesearch DNA methylase N-4/N-6search DNA methylase, N-4 cytosine-specific, conserved sitesearch S-adenosyl-L-methionine-dependent methyltransferasesearch