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THREE-DIMENSIONAL STRUCTURE OF BOMBYXIN-II, AN INSULIN-RELATED BRAIN-SECRETORY PEPTIDE OF THE SILKMOTH BOMBYX MORI: COMPARISON WITH INSULIN AND RELAXIN

Solution NMR
PDB entry 1bon coloured by chain, ensemble of 10 models, front view.
PDB entry 1bon coloured by chain, ensemble of 10 models, side view.
PDB entry 1bon coloured by chain, ensemble of 10 models, top view.
Source organism: Bombyx mori
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bombyxin A-6 B chain and Bombyxin A-2 A chain
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Multimeric state: hetero dimer
Accessible surface area: 3927.29 Å2
Buried surface area: 906.45 Å2
Dissociation area: 453.22 Å2
Dissociation energy (ΔGdiss): 9.29 kcal/mol
Dissociation entropy (TΔSdiss): 7.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147345

Macromolecules

Bombyxin A-2 A chain
Chain: A
Length: 20 amino acids
Theoretical weight: 2.19 KDa
Source organism: Bombyx mori
Expression system: Not provided
UniProt:
  • Canonical: P15411 (Residues: 70-89; Coverage: 29%)
Gene name: BBXA2
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Bombyxin A-2 A chain in PDB entry 1bon, assembly 1, front view.
Bombyxin A-2 A chain in PDB entry 1bon, assembly 1, side view.
Bombyxin A-2 A chain in PDB entry 1bon, assembly 1, top view.
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Bombyxin A-6 B chain
Chain: B
Length: 28 amino acids
Theoretical weight: 3.13 KDa
Source organism: Bombyx mori
Expression system: Not provided
UniProt:
  • Canonical: P26729 (Residues: 20-47; Coverage: 38%)
Gene name: BBXA6
Pfam: Insulin/IGF/Relaxin family
InterPro: Insulin-like superfamily
SCOP: Insulin-like
Bombyxin A-6 B chain in PDB entry 1bon, assembly 1, front view.
Bombyxin A-6 B chain in PDB entry 1bon, assembly 1, side view.
Bombyxin A-6 B chain in PDB entry 1bon, assembly 1, top view.
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