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STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS

The structure was published by Kalus, W., Zweckstetter, M., Renner, C., et al., Dony, C., Lang, K., and Holak, T.A., in 1998 in a paper entitled "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5)). This molecule has the UniProt identifier P24593 (IBP5_HUMAN)search. The sample contained 47 residues which is < 90% of the natural sequence. Out of 47 residues 46 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5)) P24593 (60-106) (IBP5_HUMAN)search Homo sapienssearch < 90% 47 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24593 (60 - 106) PROTEIN (INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5)) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Growth factor receptor domainsearch Omega-AgatoxinVsearch Insulin-like growth factor binding proteinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24593) insulin-like growth factor bindingsearch extracellular regionsearch regulation of cell growthsearch

Chain InterPro annotation
A Insulin-like growth factor-binding protein, IGFBPsearch Insulin-like growth factor binding protein, N-terminalsearch Insulin-like growth factor binding proteinsearch Insulin-like growth factor binding protein 5search Insulin-like growth factor-binding protein family 1-6, chordatasearch