1bnn Summary

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CARBONIC ANHYDRASE II INHIBITOR

The structure was published by Boriack-Sjodin, P.A., Zeitlin, S., Chen, H.H., et al., May, J.A., Dean, T., and Christianson, D.W., in 1998 in a paper entitled "Structural analysis of inhibitor binding to human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) plasma membranesearch myelin sheathsearch microvillussearch axonsearch apical part of cellsearch membranesearch cytosolsearch cytoplasmsearch basolateral plasma membranesearch extracellular spacesearch extracellular vesicular exosomesearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch one-carbon metabolic processsearch response to organic substancesearch positive regulation of synaptic transmission, GABAergicsearch bicarbonate transportsearch response to estrogensearch regulation of anion transportsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch response to pHsearch response to steroid hormonesearch secretionsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch carbonate dehydratase activitysearch metal ion bindingsearch zinc ion bindingsearch lyase activitysearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch