1bnm Summary

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CARBONIC ANHYDRASE II INHIBITOR

The structure was published by Boriack-Sjodin, P.A., Zeitlin, S., Chen, H.H., et al., May, J.A., Dean, T., and Christianson, D.W., in 1998 in a paper entitled "Structural analysis of inhibitor binding to human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch one-carbon metabolic processsearch morphogenesis of an epitheliumsearch response to estrogensearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch secretionsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch regulation of intracellular pHsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch response to zinc ionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch positive regulation of cellular pH reductionsearch response to organic substancesearch positive regulation of bone resorptionsearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch extracellular vesicular exosomesearch cytosolsearch apical part of cellsearch cytoplasmsearch plasma membranesearch microvillussearch myelin sheathsearch basolateral plasma membranesearch membranesearch axonsearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch