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STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR(SLASH)NEUROTROPHIN 3 HETERODIMER

Source organism: Homo sapiens
Biochemical function: signaling receptor binding
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00243
Domain description: Nerve growth factor family
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
The deposited structure of PDB entry 1bnd contains 1 copy of Pfam domain PF00243 (Nerve growth factor family) in Brain-derived neurotrophic factor. Showing 1 copy in chain A.
The deposited structure of PDB entry 1bnd contains 1 copy of Pfam domain PF00243 (Nerve growth factor family) in Neurotrophin-3. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002072
Domain description: Nerve growth factor-related
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
IPR029034
Domain description: Cystine-knot cytokine
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
IPR019846
Domain description: Nerve growth factor conserved site
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
IPR020430
Domain description: Brain-derived neurotrophic factor
Occurring in:
  1. Brain-derived neurotrophic factor
IPR020408
Domain description: Nerve growth factor-like
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3

Structure domain

CATH CATH domain
2.10.90.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Cystine Knot Cytokines, subunit B
Homology: Cystine-knot cytokines
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
The deposited structure of PDB entry 1bnd contains 1 copy of CATH domain 2.10.90.10 (Cystine Knot Cytokines, subunit B) in Brain-derived neurotrophic factor. Showing 1 copy in chain A.
The deposited structure of PDB entry 1bnd contains 1 copy of CATH domain 2.10.90.10 (Cystine Knot Cytokines, subunit B) in Neurotrophin-3. Showing 1 copy in chain B.
SCOP SCOP annotation
57520
Class: Small proteins
Fold: Cystine-knot cytokines
Superfamily: Cystine-knot cytokines
Occurring in:
  1. Brain-derived neurotrophic factor
  2. Neurotrophin-3
The deposited structure of PDB entry 1bnd contains 1 copy of SCOP domain 57520 (Neurotrophin) in Brain-derived neurotrophic factor. Showing 1 copy in chain A.
The deposited structure of PDB entry 1bnd contains 1 copy of SCOP domain 57520 (Neurotrophin) in Neurotrophin-3. Showing 1 copy in chain B.

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