1bn4 Summary

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CARBONIC ANHYDRASE II INHIBITOR

The structure was published by Boriack-Sjodin, P.A., Zeitlin, S., Chen, H.H., et al., May, J.A., Dean, T., and Christianson, D.W., in 1998 in a paper entitled "Structural analysis of inhibitor binding to human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 96% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytoplasmsearch microvillussearch axonsearch apical part of cellsearch extracellular exosomesearch cytosolsearch plasma membranesearch myelin sheathsearch basolateral plasma membranesearch extracellular spacesearch membranesearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch zinc ion bindingsearch arylesterase activitysearch protein bindingsearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch response to steroid hormonesearch secretionsearch response to organic substancesearch positive regulation of bone resorptionsearch response to zinc ionsearch kidney developmentsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch small molecule metabolic processsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch cellular response to fluid shear stresssearch response to estrogensearch response to pHsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch