1bmm Summary

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HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-4-[(AMINOIMINOMETHYL)AMINO]-N-[[1-[3-HYDROXY-2-[(2-NAPHTHALENYLSULFONYL)AMINO]-1-OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE (BMS-186282)

The structure was published by Malley, M.F., Tabernero, L., Chang, C.Y., et al., Roberts, D.G., Das, J., and Sack, J.S., in 1996 in a paper entitled "Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely ALPHA-THROMBIN and HIRUDIN I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L ALPHA-THROMBIN P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 77%
H ALPHA-THROMBIN P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 99%
I HIRUDIN I P28507 (54-65) (HIR3A_HIRME)search Hirudo medicinalissearch < 90% 12 75%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P00734 (328 - 363) ALPHA-THROMBIN Homo sapiens
P28507 (54 - 65) HIRUDIN I Hirudo medicinalis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
H (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
I Hirudinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
L (P00734) proteolysissearch blood coagulationsearch serine-type endopeptidase activitysearch extracellular regionsearch
H (P00734) blood coagulationsearch proteolysissearch calcium ion bindingsearch serine-type endopeptidase activitysearch catalytic activitysearch

Chain InterPro annotation
L Thrombin light chainsearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
I