1bmk Summary

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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655

The structure was published by Wang, Z., Canagarajah, B.J., Boehm, J.C., et al., Abdel-Meguid, S., Adams, J.L., and Goldsmith, E.J., in 1998 in a paper entitled "Structural basis of inhibitor selectivity in MAP kinases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (MAP KINASE P38). This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 379 residues which is 100% of the natural sequence. Out of 379 residues 351 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (MAP KINASE P38) Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 379 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) PROTEIN (MAP KINASE P38) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q16539) stress-induced premature senescencesearch positive regulation of reactive oxygen species metabolic processsearch negative regulation of canonical Wnt signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch gene expressionsearch regulation of transcription, DNA-templatedsearch toll-like receptor 10 signaling pathwaysearch transcription, DNA-templatedsearch protein phosphorylationsearch glucose metabolic processsearch cellular response to DNA damage stimulussearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch positive regulation of muscle cell differentiationsearch response to lipopolysaccharidesearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch p38MAPK cascadesearch cellular response to vascular endothelial growth factor stimulussearch peptidyl-serine phosphorylationsearch RNA metabolic processsearch intracellular signal transductionsearch response to stresssearch muscle cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch osteoclast differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of myotube differentiationsearch Ras protein signal transductionsearch cellular response to lipopolysaccharidesearch positive regulation of myoblast fusionsearch chondrocyte differentiationsearch angiogenesissearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch apoptotic processsearch regulation of transcription from RNA polymerase II promotersearch positive regulation of blood vessel endothelial cell migrationsearch chemotaxissearch positive regulation of protein import into nucleussearch DNA damage checkpointsearch cellular response to ionizing radiationsearch stress-activated MAPK cascadesearch fatty acid oxidationsearch TRIF-dependent toll-like receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of myoblast differentiationsearch activation of MAPK activitysearch mRNA metabolic processsearch platelet activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch signal transductionsearch MyD88-dependent toll-like receptor signaling pathwaysearch signal transduction in response to DNA damagesearch cartilage condensationsearch toll-like receptor signaling pathwaysearch blood coagulationsearch neurotrophin TRK receptor signaling pathwaysearch phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch innate immune responsesearch regulation of sequence-specific DNA binding transcription factor activitysearch skeletal muscle tissue developmentsearch cell morphogenesissearch response to muramyl dipeptidesearch striated muscle cell differentiationsearch positive regulation of erythrocyte differentiationsearch cellular component movementsearch nucleoplasmsearch cytoplasmsearch cytosolsearch cellsearch nucleussearch extracellular vesicular exosomesearch spindle polesearch mitochondrionsearch protein bindingsearch MAP kinase activitysearch NFAT protein bindingsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch